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HE4, OVARIAN CA MONITORING
Number 612
CPT Code 86305
Alias HUMAN EPIDIDYMIS PROTEIN 4
Specimen Container SST
Specimen Type Serum
Turn Around Time
Days Performed
Reference Range Contact Laboratory
Alternate Specimen Red Top
Volume 1 mL Serum
Stability Ambient 5 Days
Stability Refrigerated 14 Days
Stability Frozen 14 Days
Patient Preparation
No special patient preparations are required.
Methodology
Enzyme-linked immunoabsorbent assay (ELISA)
Limitations
HE4 levels tend to be higher in older women and in women who began menstruating at an older age, but these affects are small.1 Falsely elevated or depressed values of HE4 may occur in samples containing human antimouse antibodies.2 Levels of HE4 within the reference range do not preclude the presence of cancer, nor are elevated results an absolute indication of malignancy; thus, HE4 should not be used for cancer screening.2 HE4 should not be used for monitoring patients with mucinous or germ cell ovarian cancer. Results should be interpreted in conjunction with other clinical and laboratory findings.
Rejection Criteria
Nonserum sample
Additional Instructions
Performing Laboratory Reference Laboratory
TagsOVARIAN, CARCINOMA