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ANTI-THROMBIN ACTIVITY
Number 724
CPT Code 85301
Alias ANTITHROMBIN III ACITIVITY, ANTITHROMBIN III FUNCTIONAL, FACTOR XA INHIBITOR, HEPARIN COFACTOR ACTIVITY, SERINE PROTEASE INHIBITOR
Specimen Container Blue Top Citrate
Specimen Type Plasma Citrate
Turn Around Time
Days Performed
Reference Range Contact Laboratory
Alternate Specimen
Volume 2 mL Plasma
Stability Ambient Unstable
Stability Refrigerated Unstable
Stability Frozen Preferred
Patient Preparation
Methodology
The patient plasma is mixed with heparin and thrombin. The extent of thrombin inhibition is proportional to the AT concentration of the patient sample. Residual thrombin activity is measured as the rate of conversion of a chromogenic substrate and is used to calculate AT concentration.
Limitations
Rejection Criteria
Severe hemolysis; improper labeling; clotted specimen; specimen diluted with IV fluids; samples thawed in transit; improper sample type; sample out of stability
Additional Instructions
Performing Laboratory Reference Laboratory
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