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SIROLIMUS
Number 1252
CPT Code 80195
Alias RAPAMUNE
Specimen Container Lavender Top
Specimen Type Whole Blood EDTA
Turn Around Time
Days Performed
Reference Range 3.0-20.0 ng/mL
Alternate Specimen
Volume 3 mL Whole Blood
Stability Ambient 14 Days
Stability Refrigerated 14 Days
Stability Frozen 14 Days
Patient Preparation
Methodology
Liquid chromatography/tandem mass spectrometry (LC/MS-MS)
Limitations
Rejection Criteria
Additional Instructions
Sirolimus may be administered in conjunction with cyclosporine (CsA) and corticosteroids to reduce or prevent host graft rejection. Using this therapy, peak concentrations are achieved in one to two hours. The mean terminal elimination half-life is 62 hours.1 Drug-drug interactions, including CsA, may alter the pharmacokinetics of sirolimus, making therapeutic drug monitoring appropriate.
Performing Laboratory Reference Laboratory
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